Cross-linked and pH sensitive supported polymer bilayers from polymersomes - studies concerning thickness, rigidity and fluidity.

نویسندگان

  • Jens Gaitzsch
  • Dietmar Appelhans
  • Andreas Janke
  • Maria Strempel
  • Petra Schwille
  • Brigitte Voit
چکیده

Polymersomes are at the leading edge of biomedical and nanoparticle research. In order to get closer insights into their mechanical properties, the bilayer forming them needs to be studied thoroughly. Here, we report on the bilayer formation, swelling behaviour, rigidity and fluidity of our membranes derived from pH sensitive and photo-cross-linkable polymersomes.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The effect of chain length on protein solubilization in polymer-based vesicles (polymersomes).

Using a mean-field analysis we derive a consistent model for the perturbation of a symmetric polymeric bilayer due to the incorporation of transmembrane proteins, as a function of the polymer molecular weight and the protein dimensions. We find that the mechanism for the inhibition of protein incorporation in polymeric bilayers differs from that of their inclusion in polymer-carrying lipid vesi...

متن کامل

Cross-linked polymersomes as nanoreactors for controlled and stabilized single and cascade enzymatic reactions.

Polymeric vesicles or polymersomes are one of the supramolecular entities at the leading edge of synthetic biology. These small compartments have shown to be feasible candidates as nanoreactors, especially for enzymatic reactions. Once cross-linked and equipped with a pH sensitive material, the reaction can be switched off (pH 8) and on (pH 6) in accordance with the increased permeability of th...

متن کامل

Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin.

We report a new crosslinked polymersome with pH-responsive swelling properties through acidic hydrolysis of hydrophobic contents from the amphiphilic polymer chains. Its unique stability under physiological conditions and large swelling capability under low pH conditions give this polymersome promising potential for anticancer drug delivery.

متن کامل

Physisorbed Polymer-Tethered Lipid Bilayer with Lipopolymer Gradient

Physisorbed polymer-tethered lipid bilayers consisting of phospholipids and lipopolymers represent an attractive planar model membrane platform, in which bilayer fluidity and membrane elastic properties can be regulated through lipopolymer molar concentration. Herein we report a method for the fabrication of such a planar model membrane system with a lateral gradient of lipopolymer density. In ...

متن کامل

Synthetic polyion-counterion transport systems in polymersomes and gels.

Transport across the membranes of polymersomes remains difficult in part due to the great thickness of the polymer bilayers. Here, we report that dynamic polyion-counterion transport systems are active in fluorogenic polymersomes composed of poly(dimethylsiloxane)-b-poly(2-methyloxazoline) (PDMS-PMOXA). These results suggest that counterion-activated calf-thymus DNA can act as cation carrier th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Soft matter

دوره 10 1  شماره 

صفحات  -

تاریخ انتشار 2014